[Research Paper] Antibodies to human papillomavirus types 6, 11, 16 and 18: Vertical transmission and clearance in children up to two years of age
Monica Zahreddine, Marie-Hélène Mayrand, Christian Therrien, Andrea Trevisan, Carole Dagenais, Patricia Monnier, Louise Laporte, Joseph Niyibizi, Catherine Deshaies, Ana Maria Carceller, William Fraser, Paul Brassard, Jacques Lacroix, Marie-Josée Bédard, Isabelle Girard, Franàßois Audibert, Franàßois Coutlée, Helen Trottier | thelancet.com | 2020-04-07
Background: There is a paucity of data on the dynamics of human papillomavirus (HPV) antibodies in children. We aimed to describe the vertical transmission and clearance of antibodies against HPV6, 11, 16 and 18 in children.Methods: We used data from pregnant women recruited into the HERITAGE cohort study between 2009 and 2012 who were positive for HPV-DNA at baseline. Dried blood spots were collected during the first trimester in pregnant participants, and at birth, 6, 12, and 24 months of age in children.
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